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Notably, people in Africa with APOE-E4 alleles have lower AD risk compared to African Americans with similar genotypes, presumably because of differences in their food environments and lifestyles. A recent study found that those who consumed a diet low in saturated fat with a low glycemic index showed reduced biomarkers of AD and that this effect was more pronounced in those with APOE-E4. This study corroborates data from epidemiological studies. Other research has shown that adherents to a Mediterranean diet can lower the rate of cognitive decline, irrespective of APOE status. Beyond APOE, variants in genes involved in cholesterol, iron, folic acid and vitamin B12 metabolism are also linked with AD risk. We can reasonably assume that many disease-risk genetic variants were once beneficial, enabling our ancestors to adapt to specific diet and nutrient environments, said Chifeng Ma, PhD, Lead Bioinformatics Scientist at GB HealthWatch. Therefore, analyzing population genetics and the nutritional profiles of traditional diets in regions with the highest frequencies of disease risk variants could uncover the precise nutritional configurations required for preventing or treating such diseases. I am confident this project will lead to insightful discoveries that we can use to combat Alzheimers disease. At GB HealthWatch, we are synthesizing evidence-based dietary and lifestyle plans to offset genetic risks using digital technology as a mode of delivery, said Christina Troutner, MS, RDN, Research Dietitian and Nutrition Scientist at GB HealthWatch. Our company developed the HealthWatch 360 mobile app , which tracks dietary intake, physical activity and health-related symptoms while providing interactive dietary and nutritional recommendations. The app has an established data structure and algorithms capable of providing personalized food and nutrition recommendations that can be further personalized to match individual food preferences. The current version of the HealthWatch 360 app allows users to select HealthWatch Goals, such as weight control, heart health and type 2 diabetes, and receive nutritional recommendations based on medical nutrition therapy (MNT) guidelines, the 2015-2020 Dietary Guidelines for Americans, and Dietary Reference Intakes by the Food and Nutrition Board, Institute of Medicine, National Academies. The app analyzes the users food and exercise logs and provides daily reports and a nutrition score based on their diet quality and nutritional intake.

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